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We aimed to design a radiomics model for differential diagnosis of thyroid carcinoma based on dynamic ultrasound video, and compare its diagnostic performance with that of radiomics model based on static ultrasound images. Between January 2019 and May 2021, 890 patients with 1015 thyroid nodules (775 for training, 240 for validation) were prospectively enrolled. In total 890 patients underwent thyroidectomy within 1 month, and ultrasound dynamic video and static images were both acquired. Two deep learning (DL) models, namely DL-video and