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7, low AST (HR 1.13), high GGT (HR 1.25), and high DRR (HR 1.68). Low ALT and high DRR predicted CVD mortality. Low ALT (HR 1.91), low AST (HR 1.16), high GGT (HR 1.4, and high DRR (HR 1.76) predicted other cause mortality. Low ALT and high DRR were associated with increased CVD and cancer mortality. All serum liver enzyme measures were associated with all-cause mortality and other cause mortality in the US elderly population. Further studies may validate these findings in other elderly populations. Low ALT and high DRR were associat