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05, n = 70, 65 and 18 respectively). This association was not observed in the descending aorta or in SCAD patients. In contrast, the PHACTR1 locus was not associated with changes in endothelial cell function with no association between the rs9349379 locus and in vivo or ex vivo vascular function observed in CAD patients. This finding was confirmed in our murine model where loss of Phactr1 on the pro-atherosclerosis ApoE-/- background did not alter ex vivo vascular function. In conclusion, we have shown a role for PHACTR1 in arterial co