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It has previously been suggested that Alzheimer's disease (AD) and osteoporosis (OP) were related. However, the connection between these 2 disorders is poorly understood. This study aimed to investigate the relationship between amyloid β peptide (Aβ) and the osteoporotic deficit observed in AD patients. We used the APP/PS1ΔE9 transgenic mouse model of AD for study and extracted bone marrow mesenchymal stem cells (BMSCs) for in vitro studies. For experiments, mice femurs were put through a μ-computer tomography (μ-CT) scanning and after w
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