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Undoubtedly, HNK and chloroquine (CQ) show synergistic inhibition of breast cancer cells and HNK-CQ combination therapy successfully prevents breast tumorigenesis and metastatic progression. Tumor-dissociated cells from HNK-CQ treated tumors exhibit abrogated invasion and migration potential. Together, these outcomes implicate that cancer of the breast cells undergo cytoprotective autophagy to prevent HNK and a combined treatment with HNK and CQ is a promising therapeutic strategy
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