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Of 53 cardiovascular disease studies retrieved, 7 met the inclusion criteria, of which 6 contained MAs. Results were mixed for various periodontal interventions lowering the risk for cardiovascular outcomes. Only one SR used cardiovascular events as a direct outcome; the other 6 used various surrogate measures. Bradford Hill criteria analysis failed to support a causal relationship between periodontal disease and cardiovascular disease. Bradford Hill criteria analysis failed to support a causal relationship between periodontal disease and