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3 software. Results This study will synthesize the data from the present eligible high quality RCTs to assess whether VNS is effective and safety for DRE. Conclusion This study will provide systematic evidence of VNS for the treatment of patients with DRE. Systematic review registration INPLASY202040086.Background Postoperative nausea and vomiting (PONV) is a common complication after surgery. However, drugs cannot prevent it completely, and acupuncture therapy shows the potential in preventing PONV, yet the best choice hasn't been demonst