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Objective To optimize photobiomodulation therapy (PBMT) for spinal cord injury (SCI) by studying the effect(s) of irradiation parameters and position of PBMT on injury site using Monte Carlo simulation and a three-dimensional voxelated SCI rat phantom model. Background Several studies used a range of irradiation parameters and surface irradiances to calculate the fluence delivered to the SCI site. However, most have ignored factors such as the optical properties of tissues, irradiation parameters, and position. Therefore, although such stu