https://www.selleckchem.com/pr....oducts/ripasudil-k-1
Consistently with our previous study, the TIMP-1-CD63 signaling promoted survival of breast cancer cells. Interestingly, breast carcinoma cell survival was drastically reduced upon shRNA-mediated knockdown of CAIX expression, demonstrating the significance of CAIX-regulated pH in the TIMP-1-CD63-mediated cancer cell survival. Taken together, the present study demonstrates the functional significance of TIMP-1-CD63-CAXI signaling axis in the regulation of tumor metabolism, extracellular acidosis, and survival of breast carcinoma.
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