https://www.selleckchem.com/pr....oducts/ex229-compoun
BACKGROUND Obliterative bronchiolitis (O remains the major complication limiting long-term survival of patients after lung transplantation. We aimed to explore the effects of the selective Nlrp3 inflammasome inhibitor MCC950 on the pathogenesis of OB. METHODS Mouse orthotopic tracheal transplants were performed to mimic OB. MCC950 (50 mg/kg) or saline was intraperitoneally injected daily. The luminal occlusion rate and collagen deposition were evaluated by HE and Masson's trichrome staining, respectively. Infiltration of CD
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