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5 years). After one course, the response rates (partial response or better) on arms A, B, and C were 14% (95% CI, 5 to 3, 14% (5 to 31), and 32% (18 to 51). An additional five, five, and four patients met New Approaches to Neuroblastoma Therapy Minor Response criteria on arms A, B, and C, respectively. On arms A, B, and C, rates of any grade 3+ nonhematologic toxicity after first course were 19%, 49%, and 35%. Vorinostat and MIBG is likely the arm with the highest true response rate, with manageable toxicity. Vincristine and irinoteca
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