https://www.selleckchem.com/pr....oducts/BafilomycinA1
The application of oxidative and glucolipotoxic stresses markedly increased the degree of SIAS of HUVECs, represented by increased SA-β-Gal immunopositivity and p16 protein expression. Aggravation of ER stress and inflammatory response were also observed through increased levels of ATF4, CHOP, peIF2α, NOX4, NLRP inflammasome, LDH, and IL1β. These changes were markedly reversed by the administration of anagliptin. The DPP-4 inhibitor anagliptin effectively protects HUVECs against SIAS, suggesting its potential use in the developmen
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