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1%), G1-2 diarrhea (21.1%) and G1-2 nausea (17.7%). The ORR was 57.3%. Stable disease was observed in 29.1% of patients, with a disease control rate of 86.4%. With a median follow-up of 18months, the median PFS was 10.0months (95% confidence interval [CI] 8.5-11.4), while the median OS was 18.0months (95% CI 16.0-19.9). No statistically significant difference was observed between the regimens in terms of ORR, PFS (p=0.908), and OS (p=0.832). This study shows that with an appropriate design, including reduced doses, vulnerable older pati
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