https://www.selleckchem.com/pr....oducts/Aloxistatin.h
Youth-onset type 2 diabetes is a disease of pubertal onset, associated with additional burden of pubertal insulin resistance on the β-cell. Evaluate the impact of metformin treatment during puberty, a critical window of cardiometabolic change, on insulin sensitivity (Si) and compensatory β-cell response in youth with obesity. Pediatric academic hospital clinical translational research center. Healthy youth in early puberty [Tanner stage (T) 2-3] with normoglycemia and obesity (n = 44). Double-blinded placebo-control trial of metform
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