https://www.selleckchem.com/pr....oducts/pifithrin-alp
Analyses of qRT-PCR and IRF5 ASO treatment significantly reduced macrophage numbers, expression in resident-but not infiltrating-macrophages, and the severity of cystic disease. In addition, IRF5 ASO treatment in 1K mice reduced expression in resident macrophages, which was correlated with reduced STAT3 phosphorylation and downstream p-STAT3 target gene expression. These data suggest that promotes inflammatory cytokine production in resident macrophages resulting in accelerated cystogenesis. These data suggest that Irf5 promotes
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