https://www.selleckchem.com/pr....oducts/kb-0742-dihyd
Thus, TMEM173 is a key regulator of blood clotting during lethal bacterial infections. Optogenetic perturbations, live imaging, and time-resolved ChIP-seq assays in Drosophila embryos were used to dissect the ERK-dependent control of the HMG-box repressor Capicua (Cic), which plays critical roles in development and is deregulated in human spinocerebellar ataxia and cancers. We established that Cic target genes are activated before significant downregulation of nuclear localization of Cic and demonstrated that their activ
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