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At 4 weeks postoperatively, the regenerated cartilage area at the surgical site showed a larger safranin O-positive area in the ACI group (2.73 ± 4.46 mm ) than in the combined ACI and PRP group (1.71 ± 2.04 mm ). Calcified bone formation in the ACI group was relatively lower than that in the other groups. Cartilage repair failure occurred in all groups at 12 weeks postoperatively. The authors found no positive effects of PRP on the outcomes of ACI in a rabbit model. There was a smaller safranin O-positive region with the addition of PRP
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