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RS2 used the symmetric RCV value without eliminating outliers, while RS3 combined RCV and outliers. When using the rCoeV and OS1strategies, an overestimation of the CV value was obtained. Our study presents a new strategy for obtaining robust CV estimates using an indirect method together with the value of symmetric RCV to select the target population. The CV estimates obtained show a good correlation with those published in the EFLM-BVD database. Furthermore, our strategy can resolve some of the limitations encountered when using direc
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