https://pdisignals.com/index.p....hp/the-actual-foreca
Therefore, we hypothesized that a DNA methyl transferase inhibitor, Decitabine, may mitigate irritation and improve success by inhibiting the NF-κB signaling pathway. To test the theory, mice challenged with caecal ligation and puncture (CLP) had been subcutaneously injected with Decitabine answer (0.5, 1, and 1.5 mg/kg) 2 h after procedure. Our results indicated that Decitabine reduces DNA methyltransferases (DNMTs), attenuates NF-κB activation, downregulates inflammatory cytokine levels,
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