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The timing and located area of the establishment regarding the viral reservoir during acute HIV infection continue to be confusing. Making use of longitudinal bloodstream and tissue examples obtained from HIV-infected people in the earliest phase of disease, we display that frequencies of infected cells reach maximal values in gut-associated lymphoid structure and lymph nodes as soon as Fiebig phase II, before seroconversion. Both tissues exhibited greater frequencies of contaminated cells than bloodstream unti
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