https://www.selleckchem.com/pr....oducts/pemigatinib-i
Assays and SAXS experiments performed in the presence and absence of DNA, show that XthA inhibits LigA by specifically engaging with the latter's BRCT-domain to prevent it from encircling substrate DNA. Overall, the study suggests a coordinating function for XthA whereby it engages initially with LigA to prevent the undesirable consequences of futile cleavage and ligation cycles that might derail bacterial BER. © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.Type IA topoisome
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