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Fundamental to elective therapy is the role of ADAMTS 13 activity monitoring, and impact of reduced ADAMTS13 activity on end organ damage. This review discusses monitoring and treatment strategy for long-term management of TTP, including the variety of therapies available to maintain remission, prevent relapse and a summary of a long-term treatment pathway.The introduction of extended factor IX (FIX) products has significantly facilitated the treatment of hemophilia B patients. However, optimal perioperative management remains a topic of
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