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Leads to the bone tissue muscle of postmenopausal weakening of bones rats, the amount of phospho-PI3K (p-PI3K), p-Akt, and p-phosphoinositide-dependent kinase-1(PDK1) were substantially reduced (p less then 0.05). In rat model osteoblasts, the overexpression of AK0 gene upregulated the phosphorylation amount of AKT, while the interference with little interfering RNA (siRNA) in AK0 gene decreased compared to AKT. Slamming out AK0 gene led to the down-regulation of phosphorylation standard of AKT in cells. Furt
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